CUSTODIOL®-CE HTK BRETSCHNEIDER®

Organ Transplantation & Preservation Solutions

The trusted HTK organ preservation solution used in millions of transplantation procedures worldwide from donor organ to recipient, at every step.

Organ transplantation is one of the most advanced and complex applications of modern medicine. At the core of a successful transplantation process lies the preservation of the organ’s viability and functional integrity from the donor to the recipient.

CUSTODIOL®-CE HTK BRETSCHNEIDER® is the original Histidine–Tryptophan–Ketoglutarate (HTK) organ preservation solution developed by Prof. Hans J. Bretschneider and Dr. Franz J. Köhler. Used in more than 90 countries worldwide, it has become one of the most trusted solutions in millions of organ preservation and transplantation procedures.

ISCHEMIA PROCESS

Why Is Organ Preservation Important?

After donor organs are retrieved, they are separated from natural blood circulation and oxygen supply. During this period, various cellular injuries threatening organ function may develop. CUSTODIOL® HTK has been developed to help slow organ metabolism and preserve cellular structure.

Risks That May Arise During the Ischemia Process

  • Cellular energy loss
  • Metabolic acidosis
  • Cell membrane damage
  • Cellular edema
  • Free radical formation
  • Ischemia and reperfusion injury
FORMULATION

The Preservation Mechanism of CUSTODIOL® HTK

Histidine / Histidine-HCl Buffer SystemThanks to its high-concentration Histidine content, it provides strong buffering capacity to help reduce metabolic acidosis that may occur during ischemia. Supports the maintenance of intracellular pH balance.

TryptophanHelps protect cell membranes and supports the maintenance of cellular integrity.

α-KetoglutarateAn important component of energy metabolism, α-Ketoglutarate contributes to the preservation of cellular energy reserves by supporting ATP production.

MannitolThanks to its antioxidant and osmotic properties, helps reduce cellular edema formation and provides protection against free radicals.

Low Viscosity Its low viscosity enables rapid and homogeneous perfusion of organs and supports the cooling process.

INDICATIONS

Areas of Use

Kidney Transplantation

CUSTODIOL® HTK is widely used for the preservation and transport of the donor organ in kidney transplantations.

Liver Transplantation

Provides reliable protection from organ retrieval to implantation in liver transplantations.

Heart Transplantation

Used for the preservation of the donor heart and its safe delivery to the transplantation center.

Pancreas Transplantation

Supports the transplantation process by helping protect the delicate structure of the pancreas.

Multi-Organ Transplantation

 Preferred in complex transplantation procedures where multiple organs must be retrieved, preserved and transported from the same donor.

Donor Organ Storage & Transport

Used for the preservation of organs under hypothermic conditions and their safe delivery to transplantation centers.

CLINICAL ADVANTAGES

Advantages in Organ Transplantation

Long-Proven ReliabilityUsed in millions of transplantation and surgical procedures worldwide. Supported by more than 900 scientific publications, CUSTODIOL® HTK has become a reliable reference point in the field of organ preservation.

High Systemic Tolerance The majority of its components consist of substances physiologically present in the body, providing high tolerance throughout the transplantation process.

Physiological OsmolarityOffers a balanced environment for organ preservation with an osmolarity value of 290 mOsm/kg.

Strong Antioxidant SupportProvides protection against free radicals through Histidine and Mannitol. Helps reduce cellular damage during ischemia and reperfusion.

Low Viscosity & Effective PerfusionContributes to homogeneous perfusion and rapid cooling of organs, ensuring equal distribution throughout the organ.

Ready-to-Use FormulationReady for direct use without any filtration or additional additives. Provides time and practicality advantages in operational processes.

UNDER HYPOTHERMIC CONDITIONS

Organ Preservation Durations

Maximum cold ischemia tolerance durations achievable with CUSTODIOL® HTK under appropriate hypothermic conditions

48 hours

Kidney

Cold ischemia tolerance

15 hours

Liver

Cold ischemia tolerance

15 hours

Pancreas

Cold ischemia tolerance

4 hours

Heart

Cold ischemia tolerance

CUSTODIOL® HTK

Why CUSTODIOL® HTK?

  • ✓The original internationally recognized HTK solution in organ preservation
  • ✓Used in kidney, liver, heart and pancreas transplantations
  • ✓Effective organ perfusion with low viscosity
  • ✓Powerful Histidine buffer system
  • ✓Special formulation supporting cellular energy metabolism
  • ✓Antioxidant and anti-edema protection
  • ✓Ready-to-use formulation
  • ✓Used in more than 90 countries
  • ✓Millions of successful applications
  • ✓Clinical experience supported by more than 900 scientific publications

As Dr. Köhler Medikal, as the authorized main distributor of CUSTODIOL®-CE HTK BRETSCHNEIDER® in Türkiye, we provide sales, technical support and clinical training services to organ transplantation centers, university hospitals and healthcare institutions.

Our goal is to contribute to successful transplantation outcomes by ensuring transplantation teams have access to reliable organ preservation solutions, and to support the improvement of patient quality of life.